| Pair Name | Helichrysetin, Tumor necrosis factor-alpha | ||
| Phytochemical Name | Helichrysetin (PubChem CID: 6253344 ) | ||
| Anticancer drug Name | Tumor necrosis factor-alpha (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Helichrysetin, Tumor necrosis factor-alpha | |||
| Disease Info | [ICD-11: 2F7Z] | Glioma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Down-regulation | Phosphorylation | CHUK | hsa1147 | |
| Down-regulation | Phosphorylation | EGFR | hsa1956 | |
| Down-regulation | Phosphorylation | NR2C2 | hsa7182 | |
| Up-regulation | Activity | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
| Result | Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. Int J Mol Med. 2021 Apr;47(4):49. doi: 10.3892/ijmm.2021.4882. | Click |
